OneChoice recommendations are based on published and accepted medical data. This includes Infectious Disease Society of America (IDSA) and the CDC guidelines. Antibiotic choices are based on intended use information on the FDA drug label.

Arkstone only references primary sources and does not rely on secondary sources such as treatment guides. The references used in determining treatment recommendations can be accessed via OneChoice Plus through the QR code on each report. All the literature used by Arkstone is published in the reference section of the Arkstone website.