The combination of organisms and resistance detected affect the level of difficulty in treating the infection. The more complex the infection, the fewer treatment options are available. The Infection Complexity ArkScore illustrates the level of complexity in choosing a singular treatment regimen given the pathogens present and resistance genes detected.

Lower scores indicate simpler treatment scenarios, while higher scores indicate that due to the number of pathogens, the type of resistance detected, or the specific organisms themselves, treatment options are limited.